Trademarks: Nerixia
Molecular Formula: C6H17NO7P2
CAS Registry Number: 79778-41-9; 80729-79-9 (monosodium)
CAS Name: (6-amino-1-hydroxy-1-phosphonohexyl)phosphonic acid
Molecular Weight: 277.149
SMILES: ClC1=CC=CC(N2CCN(CCCCOC3=CC4=C(CCC(=O)N4)C=C3)CC2)=C1Cl
InChI Key: PUUSSSIBPPTKTP-UHFFFAOYSA-N
InChI: InChI=1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)
Activity: Treatment for Osteogenesis Imperfecta; Treatment for OI; Treatment for Paget's Disease of Bone; Treatment for Bone Diseases
Status: Launched 2002 (EU)
Originator: Abiogen Pharma
Neridronic acid synthesis: EP0494844A1 (also Ref. 2)
References:
1. Guainai-Ricci, G.; et. al. Process for the preparation of diphosphonic acids and salts thereof. EP0494844A1
2. Staibano, G. Process for the preparation of diphosphonic acids. US4705651A
3. Gatti, D.; et. al. Neridronic acid for the treatment of bone metabolic diseases. Expert Opin Drug Metab Toxicol 2009, 5(10), 1305-1311. (activity)
