Reporting
structures for novel entities without citing the primary reference is becoming
a practice now….. dangerous practice. I still see many sites still report a structure
out from thin air and other sites just go ahead with copying/editing the
information. Based on the IUPAC name derived of the structure; patents are reported,
chemistry predicted, etc.
The question
remains where the primary reference is? By primary reference, I mean the any
such article/presentation/patent etc.; where the originator has reported the
structure or activity. In absence of any primary reference, all things indicate
to something fishy. Still, it is the enduser that ends up losing value and
time.
How? Here
it is
Many reviewers
do predict the structures based upon their own knowledge/experience, but my experience
with molecules such as Brigatinib, etc has taught me that even best of reviewers
make a mistake. So, until the originator reveals the TRUE structure, things
should be reported with a disclaimer. Or, reveals the source; even if it is
bribe paid or rogue ex-employee.
Coming
back to sites with such FREE data, where not only do they sell information but also
synthesize the molecules for you; such a mistake is a costly one. You can
easily guess that much. Such a mistake is more punishable if these sites have
backing from pharmaceuticals companies.
Getting
correct free information is great achievement in this age of internet. Just
that you should know the correct source or else you end up an idiot following
an idiot.
Now explain where does these structures come from?
http://www.medkoo.com/products/8239 (the structure is provided without any reference)
https://newdrugapprovals.org/2016/03/02/suvn-g3031-from-suven-life-sciences-ltd/ (synthesis is provided for the medkoo provided structure).
Well, this magic of getting a structure and reporting synthesis is totally baffling. Let me remind you these sites have goofed-up on earlier occasions including Brigatinib.
Now explain where does these structures come from?
http://www.medkoo.com/products/8239 (the structure is provided without any reference)
https://newdrugapprovals.org/2016/03/02/suvn-g3031-from-suven-life-sciences-ltd/ (synthesis is provided for the medkoo provided structure).
Well, this magic of getting a structure and reporting synthesis is totally baffling. Let me remind you these sites have goofed-up on earlier occasions including Brigatinib.
