Trademarks: Physuline
Molecular Formula: C27H29N3O2
CAS Registry Number: 137975-06-5; 138470-70-9 (hydrochloride)
CAS Name: N-[4-[5-(dimethylamino)-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide
Molecular Weight: 427.538
SMILES:CC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N3CCCC(C4=CC=CC=C43)N(C)C
InChI Key: WRNXUQJJCIZICJ-UHFFFAOYSA-N
InChI: InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
Activity: Vasopressin Receptor Antagonist; Treatment of Hyponatremia
Status: Launched 2006 (Japan)
Originator: Otsuka
Mozavaptan synthesis: WO1991005549A1
Mozavaptan synthesis: J Med Chem 1996, 39(18), 3547-3555
References:
1. Ogawa, H.; et. al. Benzoheterocyclic compounds. WO1991005549A1
2. Ogawa, H.; et. al. Orally Active, Nonpeptide Vasopressin V2 Receptor Antagonists: A Novel Series of 1-[4-(Benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepines and Related Compounds. J Med Chem 1996, 39(18), 3547-3555.
