Common name: Loratadine; Claritin; Loratadin; SCH-29851
Trademarks: Claritin; Loratadin
Molecular Formula: C22H23ClN2O2
CAS Registry Number: 79794-75-5
CAS Name: Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
Molecular Weight: 382.88
Activity: Second-generation Antihistamines; Antihistamines; Hay Fever Treatment; Allergies Treatment; H1 Receptor Antagonist; Urticaria Treatment
Loratadine synthesis: US4282233A
Loratadine synthesis: EP1442035B1
Desloratadine synthesis: Contemporary Drug Synthesis 2004, Wiley Publication
Desloratadine synthesis: Contemporary Drug Synthesis 2004, Wiley Publication
References:
1. Vilani, F. J. No sedative effect. US4282233A
2. Cannata, V.; et. al. Process for the preparation of 4- (8-chloro-5, 6-dihydro-11h-benzo-[5,6]-cyclohepta-[1,2-b]-pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester (loratadine). EP1442035B1
3. Li, J. J.; et. al. Contemporary Drug Synthesis 2004, Wiley Publication.
4. Kay, G. G.; et. al. Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clin Exp Allergy 1999, 29(Suppl 3), 147-150. (activity)
