SUVN-
502 is a novel, potent, and selective 5-HT6 receptor antagonist with
Ki of 1.71 nM and exhibited antagonist like inhibition with EC50
of 0.103 mM. SUVN-502 is effective in animal models of cognition. In
microdialysis studies, SUVN-502 enhanced brain acetylcholine and glutamate
levels in rat ventral hippocampus and frontal cortex. SUVN-502 has completed
all regulatory safety and toxicity studies.
5-HT6
receptor a member of serotonin family predominates in brain regions associated
with cognition and behavior. The blockade of 5-HT6 receptors leads
to an improvement of cognitive performance in a wide variety of learning and
memory paradigms.
