Trademarks: Ofev; Vargatef
Molecular Formula: C31H33N5O4
CAS Registry Number: 656247-17-5
CAS Name: Methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Molecular Weight: 539.624
Activity: Oncolytic Drugs; Protein Kinase Inhibitor; VEGFR Inhibitor; FGFR Inhibitor; PDGFR Inhibitor; Tyrosine Kinase Inhibitor; Idiopathic Pulmonary Fibrosis Therapy
Nintedanib synthesis: US20110201812A1
References:
1. Merten, J.; et. al. Process for the manufacture of an indolinone derivative. US20110201812A1
2. Roth, G. J.; et. al. 3-z-[1-(4-(n-((4-methyl-piperazin-1-yl)-methylcarbonyl)-n-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition. WO2004013099A1
3. Roth, G. J.; et. al. Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480.
