Trademarks: Tafinlar
Molecular Formula: C23H20F3N5O2S2
CAS Registry Number: 1195765-45-7
CAS Name: N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
Molecular Weight: 519.56
Activity: Oncolytic Drugs; Protein Kinase Inhibitor; Serine/Threonine-Protein Kinase B-raf Inhibitor; Serine/Threonine Inhibitor
Dabrafenib synthesis: WO2009137391A2
References:
1. Adams, J. L.; et. al. Benzene sulfonamide thiazole and oxazole compounds. WO2009137391A2
2. Dabrafenib Mesylate. Drugs Future 2012, 37, 7, 469-474.
3. Waddell, J. A. and Solimando, Jr, D. A. Drug Monographs: Dabrafenib and Trametinib. Hosp Pharm 2013, 48(10), 818-821.
