Monday, March 2, 2015

Gabapentin

Common name: Gabapentin; DDS-2003; Goe-3450; CI-945; Neurontin
Trademarks:  Neurontin; Fanatrex; Gabarone; Gralise; Nupentin; Neogab
Molecular Formula: C9H17NO2
CAS Registry Number: 60142-96-3
CAS Name: 2-[1-(aminomethyl)cyclohexyl]acetic acid
Molecular Weight: 171.237
SMILES: NCC1(CC(O)=O)CCCCC1
InChI Key: UGJMXCAKCUNAIE-UHFFFAOYSA-N
InChI: InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
Activity: Anti-Anxiety Agents; Antiparkinson Agents; Analgesics; Anticonvulsants; Calcium Channel Blockers; Antimanic Agents; Treatment of Fibromyalgia; Neurologic Drugs; Neuropathic Pain
Status: Launched 1993
Originator: Pfizer

Gabapentin synthesis: US4024175A (oldest reported synthesis)
Gabapentin synthesis: US4152326 (a variation of US4024175A)
References:
1. Satzinger, G.; et. al. Gabapentin, 1-Aminomethyl-1-cyclohexane-acetic acid. US4024175A
2. Hartenstein, J. D. C.; et. al. Cyclic sulfonyloxyimides. US4152326