Common name: Dasatinib; Sprycel; BMS Dasatinib; BMS-354825
Trademarks: Sprycel
Molecular Formula: C22H26ClN7O2S
CAS Registry Number: 302962-49-8
CAS Name: N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
Molecular Weight: 488.01
Activity: Antineoplastic; Tyrosine Kinase Inhibitors
Dasatinib synthesis: US6596746B1
Dasatinib synthesis: US20130030177A1
References:
1. Das, J.; et. al. Cyclic protein tyrosine kinase inhibitors. US6596746B1.
2. Ley, S. V.; et. al. The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib. Org Biomol Chem, 2013, 11, 1766-1800.
3. Yan, R.; et. al. Synthesis process of dasatinib and intermediate thereof. US20130030177A1.
4. Dasatinib in Profiles of Drug Substances, Excipients and Related Methodology, Volume 39. Eds. Korshy, H. M. et. al. Academic Press.
